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A possible mechanism of the initiation of HSTCL
2019-04-17
A possible mechanism of the p53 tumor suppressor of HSTCL is a prolonged immunosuppressive status which generates the expansion of γδ T-cells recognizing multiple pathogens through excessive antigenic stimulation. Our cases did not have any previous illness related to immunosuppression, recurrent in
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In this case report we described a
2019-04-17
In this case report, we described a rare case of tumor lysis syndrome associated with the FOLFOX regimen and further stress the importance of additional prophylaxis for the huge tumor burden. Our patient\'s hyperammonemia may be due to cardiogenic shock, post cardio-pulmonary-cerebral resuscitation
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Expansion of access to HIV
2019-04-17
Expansion of access to HIV treatment is a global priority. In July, 2013, UNAIDS, in collaboration with WHO, the Global Fund to fight AIDS, Tuberculosis and Malaria, and the US President\'s Emergency Plan for AIDS Relief (PEPFAR) jointly issued which advocates for a worldwide treatment target of 15
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De esta poca son los
2019-04-17
De esta época son los primeros testimonios de la idea de fundar un periódico en París: en una carta del 7 de agosto de 1848, Eugène Carpentier, futuro administrador de La Tribune des Peuples, le presenta glucose transport proteins Mickiewicz un presupuesto estimado de lo que costaría un periódico. D
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En el Estudio preliminar el lector encontrar un magn
2019-04-16
En el “Estudio preliminar”, el lector encontrará un magnífico marco de referencia para ubicar con precisión la obra. Contra una vieja mala costumbre de la crítica mexicañista más convencional de repetir una y otra vez los juicios críticos de los grandes maestros, Belem Clark de Lara teje una trama m
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Further extensive FISH and molecular
2019-04-16
Further extensive FISH and molecular studies failed to detect either BCR–ABL, PDGFRA, PDGFRB and FGFR1 rearrangements or NPM1 and FLT3 mutations, whereas c-KIT D816V Puromycin was found on PB and BM mononuclear cells. Moreover, allele-specific PCR demonstrated JAK2 V617F mutation on both PB and BM
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In a revised consensus statement
2019-04-16
In 2012, a revised consensus statement for AF surgery was published by the Heart Rhythm Society/European Heart Rhythm Association/European Cardiac Arrhythmia Society as a part of the “Expert consensus statement for catheter and surgical ablation for AF” [7]. The statement was focused mainly on the r
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br Methods As we were not privy to the median
2019-04-16
Methods As we were not privy to the median year of enrolment, for all selected studies, the mean enrolment year ([start of enrolment+end of enrolment]/2) was calculated. If these dates were unavailable, the corresponding authors or sponsoring companies were contacted. When all methods to gather t
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Cell adhesion to extracellular matrix requires the interacti
2019-04-16
Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon ex
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According to the labeling of dabigatran
2019-04-16
According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage
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br Conclusion br Financial support This research was support
2019-04-16
Conclusion Financial support This research was supported by a grant from the ׳Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon׳ [GRS 308/A/08] and ‘Caja Burgos Foundation’ [Convocatoria 2007].The funding organization had no involvement in the study. Clinical trial registra
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Sulfo-NHS-Biotin cost Cardiovascular magnetic resonance imag
2019-04-16
Cardiovascular magnetic resonance imaging (CMR) is recognized as a versatile, safe, and reproducible technique, allowing for accurate structural and functional assessment of the heart. CMR is the gold standard for ejection fraction measurement [15–17]. Considering the technical limitations of other
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br Bile acids as therapeutic
2019-04-16
Bile acids as therapeutic agents Conclusion Bile acids are important physiological agents for nutrient prostaglandin receptors and integrators of glucose, lipid, and energy metabolism control. Bile acid synthesis is tightly regulated to maintain metabolic homeostasis and prevent accumulation o
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Transformation of sanitation related knowledge into
2019-04-16
Transformation of sanitation-related knowledge into routine practice is hindered by traditional mindsets and the absence of awareness and an attitude to learn. Poverty has been described as a barrier to following safe hygiene practices. Regular use of footwear is equally important for the prevention
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The multivariable analyses by Keats and colleagues identifie
2019-04-15
The multivariable analyses by Keats and colleagues identified factors associated with higher coverage of key interventions in Kenya. Current and prospective efforts tracking key indicators and their determinants over time could enable time-series regression and more sophisticated causal inference an
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