• br Methods As we were not privy to the median

  2019-04-16

  

  Methods As we were not privy to the median year of enrolment, for all selected studies, the mean enrolment year ([start of enrolment+end of enrolment]/2) was calculated. If these dates were unavailable, the corresponding authors or sponsoring companies were contacted. When all methods to gather t

• Cell adhesion to extracellular matrix requires the interacti

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  Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon ex

• According to the labeling of dabigatran

  2019-04-16

  

  According to the labeling of dabigatran in Japan, patients to be considered for the prescription of the lower dose of 220mg/day are as follows: (1) aged ≥70 years, (2) with moderate renal impairment (ClCr 30–50mL/min), (3) concomitant use of a p-glycoprotein inhibitor, and (4) history of hemorrhage

• br Conclusion br Financial support This research was support

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  Conclusion Financial support This research was supported by a grant from the ׳Gerencia de Salud, Consejería de Sanidad, Junta de Castilla y Leon׳ [GRS 308/A/08] and ‘Caja Burgos Foundation’ [Convocatoria 2007].The funding organization had no involvement in the study. Clinical trial registra

• Sulfo-NHS-Biotin cost Cardiovascular magnetic resonance imag

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  Cardiovascular magnetic resonance imaging (CMR) is recognized as a versatile, safe, and reproducible technique, allowing for accurate structural and functional assessment of the heart. CMR is the gold standard for ejection fraction measurement [15–17]. Considering the technical limitations of other

• br Bile acids as therapeutic

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  Bile acids as therapeutic agents Conclusion Bile acids are important physiological agents for nutrient prostaglandin receptors and integrators of glucose, lipid, and energy metabolism control. Bile acid synthesis is tightly regulated to maintain metabolic homeostasis and prevent accumulation o

• Transformation of sanitation related knowledge into

  2019-04-16

  

  Transformation of sanitation-related knowledge into routine practice is hindered by traditional mindsets and the absence of awareness and an attitude to learn. Poverty has been described as a barrier to following safe hygiene practices. Regular use of footwear is equally important for the prevention

• The multivariable analyses by Keats and colleagues identifie

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  The multivariable analyses by Keats and colleagues identified factors associated with higher coverage of key interventions in Kenya. Current and prospective efforts tracking key indicators and their determinants over time could enable time-series regression and more sophisticated causal inference an

• In order to treat metastatic bone disease

  2019-04-15

  

  In order to treat metastatic bone disease effectively all steps involved in the metastatic cascade need to be taken into account as for example the interactions between primary and secondary sites, tumour cell–bone cell cross talk and osteomimicri [8]. Therefore, concomitant targeting of both the tu

• The exact incidences of amiodarone induced hyperthyroidism a

  2019-04-15

  

  The exact incidences of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism currently remain unknown; however, the reported frequencies of amiodarone-induced hyperthyroidism and amiodarone-induced hypothyroidism vary widely from 0.8% to 37.8% [7–16] and from 1% to 32% [13,17–20]

• El an lisis de Close merece una continuaci n

  2019-04-15

  

  El análisis de Close merece una continuación. En efecto, la narrativa mexicana actual cuenta con otros autores de novelas de crímenes que se mantienen alejados de los tópicos necro-pornográficos misóginos y del gusto sensacionalista y moralista. En lo que sigue abogaremos por la inclusión de Alejand

• Antenatal corticosteroids induce fetal lung maturation throu

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  Antenatal corticosteroids induce fetal lung maturation through the same biological mechanism in low-income settings as in high-income settings and reduce the need for neonatal mechanical ventilation. Although antenatal corticosteroids might not be a so-called magic bullet as a standalone vertical in

• The type of ventricular arrhythmia monomorphic

  2019-04-15

  

  The type of ventricular arrhythmia (monomorphic VT or polymorphic VT/VF) responsible for the electrical storm provides an important diagnostic clue to its pathophysiology (Fig. 1). In this review, we address the diagnosis and specific treatments according to the type of ventricular arrhythmia and th

• Data comparing the effectiveness of CFAE

  2019-04-15

  

  Data comparing the effectiveness of CFAE ablation and LA linear ablation for eliminating long-standing persistent AF is lacking. However, Estner et al. recently showed that CFAE ablation plus PVI in patients with persistent AF ablation approached the same effectiveness as circumferential PVI plus li

• order Deferoxamine Numerous clinical trials phase II and pha

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  Numerous clinical trials (phase II and phase III) have been then designed to evaluate the efficacy of denosumab in oncology mainly in breast and prostate bone metastases (Table 1). These studies revealed that denosumab reduced significantly bone turnover markers similarly to osteoporotic patients. M

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