• The present study determined the effect of DCA

  2023-01-14

  

  The present study determined the effect of DCA on VSMC calcification in vitro and in atherosclerotic ApoE-/- mice in vivo. We found that Busulfan non-toxic concentrations of DCA, did not affect VSMC viability, induced calcification of VSMC in culture and increased atherosclerotic vascular calcifica

• Estradiol In glaucoma the primary retinal

  2023-01-14

  

  In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor

• The direction of glutamate transport by the

  2023-01-14

  

  The direction of glutamate transport by the cell membrane transporter is reversible. As mentioned above, glutamate transport is an electrogenic process associated with a transmembrane ion gradient established by the Na+-K+ pump through hydrolysis of adenosine triphosphate. Under conditions of energy

• br Conclusions The present data suggest that homeostatic bal

  2023-01-14

  

  Conclusions The present data suggest that homeostatic balance of the cortical/hippocampal adenosinergic tone is necessary for normal working memory function and any deviation appears to impair performance – either as a consequence of A2AR under-activation when adenosine levels are reduced or due

• Nutritional factors affecting ASD have also recently receive

  2023-01-14

  

  Nutritional factors affecting ASD have also recently received attention. An increase in postsynaptic zinc (Zn) level induced by clioquinol (a Zn chelator and ionophore), and the subsequent activation of NMDA receptors through the tyrosine kinase Src, rescued social interaction in Shank2−/− mice (Lee

• br Materials and methods br Results br Discussion

  2023-01-14

  

  Materials and methods Results Discussion Cdc42 has been implicated in mediating the entry of HCV into hepatocytes, but how Cdc42 affects the response of HCV patients to IFN therapy is unknown. This study therefore examined the genetic association between Cdc42-related genes and efficacy of

• REM sleep is proposed to create an environment to

  2023-01-13

  

  REM sleep is proposed to create an environment to facilitate plasticity processes that create a generalized downregulation of synaptic strength (Grosmark et al., 2012; Tononi and Cirelli, 2014), while synapses are upregulated specifically by the reactivation of neuronal firing sequences experienced

• Specifically equity injections in a multinational affiliate

  2023-01-13

  

  Specifically, equity injections in a multinational affiliate X located in an ACE country can be passed on as lending to another group member Y located in a different country with a high corporate income tax rate. For the group member Y, the interest on the loans is tax deductible, and at the same ti

• azd2014 Many metalloenzyme inhibitors consist of two

  2023-01-13

  

  Many metalloenzyme inhibitors consist of two chemical components: the MBG, the portion of the inhibitor designed to bind to the metal, and the scaffold, the portion of the inhibitor recognized by the amino azd2014 residues that form the substrate-binding site of the metalloenzyme. The MGB is often

• br Concluding Remarks and Future Directions The physiologica

  2023-01-13

  

  Concluding Remarks and Future Directions The physiological significance of autophagy in neuronal function is steadily emerging. The studies discussed herein reveal that key neuronal functions, such as neurotransmitter release, pruning of dendritic spines, and behavioural outputs of neural network

• br Antioxidant polymers conjugates Natural antioxidants are

  2023-01-11

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic L-Arabinose sale as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Si

• br Antioxidant polymers conjugates Natural antioxidants are

  2023-01-11

  

  Antioxidant-polymers conjugates Natural antioxidants are usually used as a substitute for synthetics but some degradation phenomena could influence their applications. For example, ascorbic L-Arabinose sale as a natural antioxidant undergoes yellowish coloration as a result of oxidation [29]. Si

• Naloxone receptor BITC significantly enhanced the gene expre

  2023-01-10

  

  BITC significantly enhanced the gene expression of the Nrf2-dependent genes, such as NQO1 and HO-1 (Fig. 4), as well as the ALDH genes (Fig. 2). Nrf2 is a key transcriptional factor which activates the expression of the genes that contain ARE in their promoter. Nrf2 translocates to the nucleus where

• br Acknowledgements br Introduction Resistant

  2023-01-10

  

  Acknowledgements Introduction Resistant hypertension (RH), is defined as blood pressure (BP) > 140/90 mm Hg despite three full doses antihypertensive drugs including a diuretic. Controlled hypertensive patients taking four pepstatin or more of antihypertensives are also considered resistant (

• Nanoparticles are submicrometric systems smaller than nm

  2023-01-10

  

  Nanoparticles are submicrometric systems smaller than 1000 nm which high surface area and composite materials may allow their greater interaction with biological membranes and control of the drug release. These features are directly associated with the efficacy of treatment and the presence of adver

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